Alcohols and polyols
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- (1)
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- (1)
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- (1)
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- (1)
- (462)
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- (11)
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- (1)
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- (145)
- (114)
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- (1)
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- (1)
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- (1)
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- (1)
- (28)
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- (7)
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- (5)
- (1)
- (36)
- (5)
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- (2)
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- (17)
- (15)
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- (33)
- (4)
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- (8)
- (2)
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- (8)
- (7)
- (7)
- (2)
- (1)
- (26)
- (1)
- (1)
- (1)
- (2)
- (1)
- (3)
- (4)
- (3)
- (1)
- (15)
- (12)
- (1)
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- (2)
- (7)
- (12)
- (1)
- (14)
- (24)
- (1)
- (8)
- (4)
- (1)
- (2)
- (1)
- (17)
- (2)
- (6)
- (5)
- (2)
- (1)
- (5)
- (3)
- (4)
- (24)
- (5)
- (3)
- (5)
- (14)
- (1)
- (1)
- (1)
- (11)
- (3)
- (2)
- (4)
- (11)
- (2)
- (7)
- (4)
- (1)
- (1)
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- (6)
- (11)
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- (1)
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- (14)
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- (2)
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- (1)
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- (2)
- (10)
- (1)
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- (1)
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- (5)
- (1)
- (1)
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- (10)
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- (7)
- (1)
- (5)
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- (1)
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- (9)
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- (1)
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- (10)
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- (1)
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- (11)
- (1)
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- (378)
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Filtered Search Results
Medchemexpress LLC N,N-Dimethyl-3-(5-(2-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-indol-1-yl)propan-1-amine hydrochloride | 97.0% | C20H24ClN5O2S | 50 MG
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DC-BPi-11 hydrochloride is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. It demonstrates remarkable inhibition against leukemia cell proliferation and is suitable for laboratory research. The compound shows minimal effects on normal cells.
- Inhibits BPTF with an IC50 value of 698 nM
- Shows remarkable inhibition against leukemia cell proliferation
- Inhibits BPTF in human leukemia MV-4-11 cells with an EC50 value of 120 nM
- Significantly inhibits the proliferation of human leukemia MV-4-11 cells (IC50=0.89 μM)
- Decreases downstream oncogene expression at concentrations between 2.5-20 μM
- Dose-dependently decreases c-Myc protein level
- Shows minimal effects on normal cells, indicating its safety
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Medchemexpress LLC Eperisone (hydrochloride) | 56839-43-1 | 99.95% | 1 G
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Eperisone hydrochloride is an orally active antispastic agent with a vasodilator effect. It is used for the research of muscle stiffness and pain. This compound is a potent and selective P2X7 receptor antagonist, also exhibiting antagonism for human P2X3. It works by relaxing both skeletal muscles and vascular smooth muscles, demonstrating several beneficial effects.
- Reduces myotonia.
- Improves circulation.
- Suppresses the pain reflex.
- Preferentially suppresses lung fibroblast activity.
- Suppresses bleomycin-dependent pulmonary fibrosis.
- Not toxic to alveolar epithelial cells in vitro.
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Medchemexpress LLC Proadifen (hydrochloride) | 62-68-0 | 99.95% | 1 ML
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Proadifen hydrochloride, also known as SKF-525A, is a non-competitive Cytochrome P450 inhibitor with an IC50 value of 19 μM. It reduces monoamine oxidase A activity and N,N-dimethyltryptamine metabolism. This compound is promising for research related to metabolism-related diseases, ovarian carcinoma, inflammation, and dopamine neuron-related diseases.
- Reduces monoamine oxidase A activity
- Reduces N,N-dimethyltryptamine metabolism in liver microsomes
- Inhibits N-demethylation and Acridone formation
- Augments lipopolysaccharide-induced fever
- Exacerbates prostaglandin E2 levels in rats
- Promising for research of metabolism-related diseases
- Promising for research of ovarian carcinoma
- Promising for research of inflammation
- Promising for research of dopamine neuron-related diseases
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Medchemexpress LLC Buspirone (hydrochloride) | 33386-08-2 | 99.99 % | 1 G
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Buspirone hydrochloride is a 5-HT1A receptor agonist that can be used for anxiety and depression research.
- Has cytotoxic effect in lymphocytes.
- Induces ROS formation, MMP collapse, lipid peroxidation, lysosomal damage, and elevation of glutathione disulfide (GSSG) in lymphocytes.
- Reduces anxiety/depression behaviors in C57BL/6N mice.
- Restores IS-shifted β-diversity in the gut microbiota in C57BL/6N mice.
- Reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus.
- Reduced myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon.
- Reduced the IS- or EC-induced gut proteobacteria population.
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Medchemexpress LLC Imidapril (hydrochloride) | 89396-94-1 | MFCD00870777 | 99.9% | 100 MG
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Imidapril hydrochloride (TA-6366) is an orally active inhibitor of angiotensin-converting enzyme (ACE) and MMP-9. It works by suppressing the conversion of angiotensin I to angiotensin II, which in turn reduces total peripheral resistance and systemic blood pressure. It is used in research for hypertension, type 1 diabetic nephropathy, and chronic heart failure.
- Orally active ACE and MMP-9 inhibitor
- Suppresses conversion of angiotensin I to angiotensin II
- Reduces total peripheral resistance and systemic blood pressure
- Used in research for hypertension
- Used in research for type 1 diabetic nephropathy
- Used in research for chronic heart failure
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Medchemexpress LLC Imidapril (hydrochloride) | 89396-94-1 | 99.9% | 50 MG
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Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. It suppresses the conversion of angiotensin I to angiotensin II, reducing total peripheral resistance and systemic blood pressure. It is used for research related to hypertension, type 1 diabetic nephropathy, and chronic heart failure.
- Orally active ACE inhibitor
- MMP-9 inhibitor
- Suppresses angiotensin I to angiotensin II conversion
- Reduces total peripheral resistance
- Reduces systemic blood pressure
- Used for hypertension research
- Used for type 1 diabetic nephropathy research
- Used for chronic heart failure research
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Medchemexpress LLC Leonurine hydrochloride | 24735-18-0 | 347.79 | 100 MG
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Leonurine hydrochloride is an alkaloid isolated from Leonurus artemisia, exhibiting anti-oxidative and anti-inflammatory properties. This compound is intended for research use only, playing a role in various biological activities in vitro and in vivo.
- Causes diminution in lipid accumulation and cellular cholesterol content.
- Increases apoA-I- or HDL-mediated cholesterol efflux.
- Significantly increases the expressions of ABCA1 and ABCG1.
- Shows protective effects on cell viability of HepG2 and HL-7702 cells.
- Improves cellular lipid accumulation via activating AMPK/SREBP1 pathway.
- Inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6.
- Suppresses ECM degradation in human OA chondrocytes.
- Blocks IL-1β-induced PI3K and Akt phosphorylation.
- Ameliorates osteoarthritis development in mouse DMM model.
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Medchemexpress LLC Nifenalol hydrochloride | 5704-60-9 | 260.72 | C11H17ClN2O3 | 5 MG
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Nifenalol hydrochloride is a β-adrenergic receptor antagonist used in cardiac electrophysiology and pharmacology research. The compound is reported to induce early afterdepolarization (EAD) and is used to study arrhythmia and blood pressure-related effects.
- Beta-adrenergic receptor antagonist activity
- Induces early afterdepolarization useful for arrhythmia studies
- Hydrochloride salt form for improved solubility
- Molecular formula C11H17ClN2O3
- Molecular weight 260.72
- Available in small research pack sizes (e.g., 5 mg)
- Intended for in vitro and in vivo research applications
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Medchemexpress LLC Sultopride hydrochloride | 23694-17-9 | 99.9% | 390.93 | 1 ML
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Sultopride hydrochloride is a selective antagonist of dopamine D2 receptor.
- Selective antagonist of dopamine D2 receptor.
- Purity of 99.92%.
- Molecular weight of 390.93.
- Appears as a white to off-white solid.
- Soluble in H2O and DMSO.
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Medchemexpress LLC Benzoic acid, 4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo-1,4,9-triazaspiro [5.5]undec-9-yl]methyl]phenoxy]-, hydrochloride (1:1) | 461023-63-2 | 99.9% | 614.17 | 25 MG
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Aplaviroc hydrochloride is a CCR5 antagonist derived from SDP, with IC50s ranging from 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL, and HIV-1MOKW. It is intended for research use only.
- Target: CCR5 antagonist
- Potency: Potent activity against wild-type R5 HIV-1 strains with IC50 values of 0.1 to 0.4 nM
- Mechanism: Suppresses infectivity and replication of HIV-1MDR variants at low concentrations (IC50 values of 0.4 to 0.6 nM)
- Binding Affinity: Binds to CCR5 with high affinity (Kd value of 2.9±1.0 nM)
- Inhibition: Potently blocks rgp120/sCD4 binding to CCR5 with an IC50 value of 2.7 nM
- In Vivo Efficacy: Suppresses R5 HIV-1 viremia in hu-PBMC-NOG mice at a dosage of 60 mg/kg
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Medchemexpress LLC VU6036720 hydrochloride | 99.7% | 473.39 | 100 MG
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VU6036720 hydrochloride is a potent and specific in vitro inhibitor of Kir4.1/5.1 channels. It can inhibit these channels with an IC50 value of 0.24 μM and is suitable for research related to brain and kidney.
- Potent and specific in vitro inhibitor of Kir4.1/5.1 channels
- Inhibits Kir4.1/5.1 channels with an IC50 value of 0.24 μM
- Can be used for the research of brain and kidney
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Medchemexpress LLC AR-C102222 hydrochloride | 1781934-50-6 | 99.8% | 10MM 1ML
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AR-C102222 hydrochloride | 1781934-50-6 | 99.8% | 10MM 1ML
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Medchemexpress LLC Befiradol hydrochloride | 2436760-81-3 | 99.93% | 430.32 | 25 MG
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Befiradol hydrochloride is a selective 5-HT1A receptor agonist, suitable for research use only.
- Reduces activity of dorsal raphe serotonergic neurons
- Increases discharge rate of mPFC pyramidal neurons
- Decreases extracellular 5-HT in the hippocampus and mPFC
- Increases extracellular DA in mPFC
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Medchemexpress LLC Pirlimycin hydrochloride | 78822-40-9 | MFCD27952783 | 99.1% | 447.42 g·mol⁻¹ | C17H32Cl2N2O5S | 1 MG
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Pirlimycin hydrochloride is a lincosamide-class antibiotic supplied as the hydrochloride salt for research use. It inhibits bacterial protein synthesis by binding the 50S ribosomal subunit and is primarily active against Gram-positive organisms. The material is provided as a solid at high purity for analytical and laboratory applications.
- Lincosamide antibiotic.
- Inhibits bacterial protein synthesis via 50S ribosomal binding.
- Primarily active against Gram-positive bacteria.
- High purity (99.1%).
- Supplied as a solid suitable for analytical use.
- Available in small-scale quantities for research.
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Medchemexpress LLC Pargyline hydrochloride | 306-07-0 | MFCD00012492 | 99.91% | C11H14ClN | 100 MG
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Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with antihypertensive and anticancer activities. It functions as a click chemistry reagent, containing an Alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Irreversible monoamine oxidase (MAO) inhibitor
- Exhibits antihypertensive activities
- Demonstrates anticancer activities
- Functions as a click chemistry reagent
- Contains an alkyne group for CuAAc reactions
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